The Closing Conference of BioSysNet at a glance...

On the 14th and 15th of March the final event of the bavarian research network BioSysNet was successfully held in the BioSysM building in Großhadern. Next to our office at the event hall Römerforum we could wellcome the members of the ministry, the scientific coordinator Prof. Domdey, the advisory board and the project investigators of the Biosysnet research groups.

Also other scientists of various disciplines attended the event, so all together we had more than 100 interested visitors.

To begin the event there was a welcome by Prof. Domdey and Mrs Schmid of the Bavarian State Ministry of Education, Science and the Arts followed by the keynote speech of Prof. Cramer. Further speakers were Prof. Lamond, Prof. Stoffel and Prof. Klingmüller who also hold the chair of the advisory board.

As a highlight of the evening we could win magician Marc Gassert to show his magic show. The evening finished with a luxuriant dinner and inspiring converations.

The next day the evaluation of the junior research groups startet with their 30 minute presentations about their work and results within the Biosysnet projects.

After lunch also the associated junior and senior groups were presenting their results by 3-4 minute pitches.

For the end of the afternoon Prof. Domdey, Prof. Klingmüller, Prof. Engelhardt, Prof. Bosserhoff, Prof. Winner und Prof. Madlgot together in irder to discuss the topic " the future of research funding in Bavaria" in a penal and plenary discussion.

Further informations, the Agenda and all the fotos you can find here...


Prof. Dr. Gil Westmeyer offers new insights into brain functions

The new "NeuBtracker-Microscope" as non-invasive imaging technology

With its transparent body the zebra fish larva makes something possible scientists could only dream of on other laboratory animals: with the help of classic fluorescence microscopy it is possible to track about 100 000 nerve cells directly in the brain.
The group around Prof. Gil Westmeyer at the TU Munich and the Helmholtz-Center now developed an open-source-microscope also to study the larvas without fixing them and without any impact from outside.
The "NeuBtracker"-microscope measures simultaneously the swimming behaviour and brain activities of the larvas. With this method it was possible to see the larvas avoiding specific olfactics and to which influences they react with an increasing or decreasing of their swimming activities. The next aim will now be to improve the microscope tecnically to solve more mysteries about neural mechanisms during simple decision-making processes. Prof. Westmeyer offers construction plans and software for the new microscope at for free use and is looking forward to new cooperations with interested scientific groups.

Research group of Prof. Theis develops Scanpy

New software processes huge amounts of single-cell data

The research group of Prof. Theis has recently developed and published a program that is able to help manage enormous datasets. The software, named Scanpy, is a candidate for analyzing the Human Cell Atlas. “It’s about analyzing gene-expression data of a large number of individual cells,” explains lead author Alex Wolf of the Institute of Computational Biology (ICB) at Helmholtz Zentrum München. He developed Scanpy together with his colleague Philipp Angerer in the Machine Learning Group of Prof. Dr. Dr. Fabian Theis. In addition to his position at Helmholtz Zentrum, Theis is also a professor of mathematical modelling of biological systems at the Technical University of Munich. “New technical advances generate several orders of magnitude more data with a correspondingly greater information content,” Theis says. “However, the historically evolved software infrastructure for gene-expression analysis simply wasn’t designed to cope with the new challenges. New analytic methods are therefore needed.” 


Technologically, the application is a trailblazing development: Whereas biostatistics programs are traditionally written in the programming language R, Scanpy is based on the Python language, the dominant language in the machine learning community.  Another new feature is that graph-based algorithms lie at the heart of Scanpy. Unlike the usual approach of regarding cells as points in a coordinate system within gene-expression space, the algorithms use a graph-like coordinate system. Instead of characterizing a single cell by the expression value for thousands of genes, the system simply characterizes cells by identifying their closest neighbors – very much like the connections in social networks. 


We would like to congratulate Prof. Theis and his research group on this oustanding achievement. You can find the complete press release here. The complete publication is available for download. 

SCANPY: large-scale single-cell gene expression data analysis
Wolf et al. 2018 Genome Biology.pdf
Adobe Acrobat Dokument 1.0 MB

Bryant University visiting BioSysNet

International networking with BioM

On 19th of January 2018, BioSysNet together with BioM received 55 students and professors of the Bryant University, in order to promote a better academic and business relationship as well as to increase collaborations between the research campus Martinsried and the greater Boston area. 


Martinsried is Bavarias largest center of biotechnology. With Harvard, Cambridge, the Ivy League and other excellent private and public universities in close proximity, as well as small and large biotechnological companies, clinics, laboratories and start-ups, Boston is the American center of classical research and biotechnology. 


The members of the Bryant University, which is located less than one hour away from Boston and is considered one of the leading business schools, wanted to gain insight into how different areas of biotechnology in Bavaria are coordinated, managed and promoted at the Martinsried site. The students and professors listened to a presentation of Dr. Kääb and were able to ask detailed questions and network during a tour across the research campus Martinsried. As a result of the nice and successfull exchange new cooperations will certainly arise.

New publication in the research group of Prof. Groß

We are happy to announce the recent publication of Prof. Dr. Olaf Groß within Cell Reports and would like to congratulate the whole group on this success. The graphical overview illustrates how in the absence of GSDMD or caspase-1 protease activity the inflammasome engages an alternative type of lytic cell death and IL-1 release that contributes to immunity agains infection. 


Prof. Groß has been chair of experimental neuropathology at the medical faculty of the university of Freiburg since April 2017.


Link to the complete publication:

m4 Award for Prof. Dr. Anja Bosserhoff

With the m4 award, the Free State of Bavaria supports innovative products, technologies and services of young ventures which decisively drive the development of "personalized medicine". This year's m4 Award goes to five Bavarian research teams, whose biomedical and application-driven projects have potential for a business formation. The m4 Award consists in a prize money of 500.000 Euro for a funding period of two years, in order to further develop and validate the project idea and prepare for a spin-off company. However, in addition to the financial assistance, the scientists can count on active support through BioM, the organizer of the m4 contest, as well as other partners of the innovative landscape of Bavaria, the socalled "Gründerland Bayern".


We are especially happy to announce that BioSysNet scientist Prof. Dr. Anja Bosserhoff together with Prof. Dr. Claus Hellerbrand from the Fridrich-Alexander-University Erlangen-Nürnberg have been chosen for this year's m4 Award for their project "Development of an orally administered inhibitor for the therapy of malignant melanoma" and would like to offer our heartfelt congratulations. 


For more details on the m4 award and the award-winning project of Prof. Bosserhoff and Prof. Hellerbrand, please read here...

Dr. Ulrike Kaltenhauser: the Secret of Relationships


The director of the research network BioSysNet Dr. Ulrike Kaltenhauser wrote about the advantages of collaborations within research networks and the role of relations and contacts in the workplace published in the Summeressays of the Laborjournal. The successful business woman and graduated biologist shares her yearslong experience founding and managing the research networks BayGene, BioSysNet, For Planta and BayKliF. She describes skillfully the benefits of cultivating relations and establishing cooperations. Additionally she explains how synergy-effects of network projects contribute to higher yield and faster goal attainment.

Here you can read her article "The sectret of relationships: Why do networks simplify life and carreer.

New publication of Dr. Fabiana Perocchi

BioSysNet junior group leader, Dr. Fabiana Perocchi, has recently published an article in Molecular Cell regarding the development of a high-troughput assay that selects for small-molecule modulators specific to the human mitochondrial calcium uniporter complex. We would like to offer our heartfelt congratulations to this great success! To access this publication, please click here.

Open house and celebration of the faculty of biology

13th of July 2017 at the biocenter of the LMU

Once again, BioSysNet took part at the open house of the biocenter at the LMU. A diverse programme with short presentations and different topic workshops gave profound insight into the many different research areas and departments at the faculty of biology. There were guided laboratory tours, poster walls, stalls and booths of all research areas, an interactive quiz as well as tours through the green houses. The complete programme can be found here

New publication of Prof. Dr. Gunter Meister

A compendium of RNA-binding proteins that regulate microRNA biogenesis

We are happy to announce a new publication by Prof. Dr. Gunter Meister, one of the BioSysNet senior project leaders, and would like to offer our heartfelt congratulations! Published on 20th of April in Molecular Cell, the publication offers insight into RNA-binding proteins which are involved in the regulation of microRNA biogenesis. 


Treiber T., Treiber N., Plessmann U., Harlander S., Daiß J.-L., Eichner N., Lehmann G., Schall K., Urlaub H. & Meister G. (2017) A compendium of RNA-binding proteins that regulate microRNA biogenesis. Molecular Cell, April 20;66(2):270-284.


Direct link to PubMed

Forum Science & Health

5th/6th of July 2017 in Fürstenfeldbruck

"FORUM Science Health" gave all participants and stakeholders from the healthcare sector the opportunity to get up to date on new developments within academic and industry research aswell as innovative medicine. BioSysNet also participated with a network booth. We greatly enjoyed taking part in this exciting event! Read more...

Chinese Academy of Science - Event

20th of June 2017 in the BioSysM building of the LMU

On Tuesday, 20th of June 2017, a group of visitors from the Chinese Academy of Science (CAS) met with the Bavarian Research Networks for a scientific exchange. The CAS was especially interested in the structure of research funding in such an exceptional resesarch location as Bavaria and how networking helps the Bavarian scientists. The meeting took place as a point of initiation for future collaborations. It started out with a welcome breakfast, after which Dr. Ulrike Kaltenhauser, the managing director of BioSysNet, introduced the research management. Then, Dr. Saskia Graf from BayFOR gave an overview over German and European funding opportunities. Last but not least, Prof. Eckhard Wolf gave the visitors a tour to his laboratory facilities and provided insight into his work. The successfull event ended over lunch with animated and inspiring conversations.

IKOM Life Science

23rd of May 2017 at the Wissenschaftszentrum Weihenstephan

Like every year, BioSysNet took part at the IKOM Life Science fair at the TUM Campus in Weihenstephan. As in previous years, the research network presented itself to students from different scientific disciplines. This included answering questions, exchanging contacts, lively discussions about research fields and developments as well as recommendations for academic internships and scientific assignments. It was a very informative and memorable day for everyone!

Science communication in times of digital media          - an interactive event presented by BayFOR

Science communication for research networks 2.0: Social media, YouTube, blogging Twitter & Co. After an overview given by Andrea Geipel from the Munich Center for Technology in Society of the TU Munich, Michael Meyen, the speaker of the research network FORCHANGE, presented the social science FORCHANGE blog on resilience. The main speaker was Lars Fischer, who is well known for his scientific „Fischblog“ initiated in 2007 and has been a Community Manager at the Blogportals SciLogs of Spektrum der Wissenschaft since 2008. He shared with us his everyday work and spoke about theoretical and practical aspects of scientific blogging. During the subsequent panel discussion, new ideas and thoughts were introduced and discussed. 

32nd meeting of the VBU business network for female managers in life sciences

24th of March 2017 at MorphoSys AG in Planegg

Every company starts with an idea - but how das an idea turn into a company? At the 32nd meeting of the VBU business network for female managers in Life Sciences, this question was elaborated on the basis of personalized medicine. Presentations from clinical and industrial experts were key to this event titled „Personalized medicine - from the lab to a global player“. Being an experienced manager in Life Sciences, Dr. Ulrike Kaltenhauser, managing director of BioSysNet, also took part. 

Leibniz Prize goes to two BioSysNet researchers

Prof. Jörg Vogel and Prof. Karl-Peter Hopfner receive award on     15th of March 2017

BioSysNet scientist Prof. Bosserhoff obtains great honor - appointment to the federal scientific council

BioSysNet senior group leader Prof. Anja Bosserhoff of the Institute for Biochemistry at the Friedrich-Alexander-Universität Erlangen-Nürnberg will be part of the federal scientific council (Wissenschaftsrat) from February 2017 onwards. The scientific council is the most important political advisory body regarding science policy in Germany. It was founded in 1957 and advises federal and state governments on matters such as the contentual and structural development of the university system as well as the federal funding of research institutions. More information can be found on the official homepage. We would like to congratulate Prof. Bosserhoff on this great honor!

Lunch Seminar "On Technology Innovation"

24th of January 2017                                                                     in the BioSysM building at Großhadern Campus


The BioSysNet Lunch Seminar "On Technology Innovation" on 24th of January 2017 took place in cooperation with the company siTOOLs as well as Prof. Gunter Meister and Prof. Dr. Peter Dietrich. The seminar's topic was "Focus on Specificity: Genetic Manipulation with RNAi and CRISPR"  - the main goal was to discuss this new technology and its practical implementation, taking into account users, experts and the companies which provide technological solutions. The event was well attended and drew the attention of many scientists. It concluded in a fruitful discussion about practical use and problems for scientific research. BioSysNet was represented through the managing director, Dr. Ulrike Kaltenhauser, as well as the scientific head of the network, Prof. Dr. Horst Domdey. 

Network meeting of BioSysNet

2nd of December 2016 at the IZB in Großhadern

6th Munich Biomarker Conference

29th/30th of November 2016                                                       Ramada Hotel & Conference Center Munich Messe

On November 29 and 30, 230 experts from all over Europe participated in the 6th Munich Biomarker Conference in Munich. The international conference on personalized medicine was organized by BioM, the network agency of Bavaria’s biotechnology industry. Interdisciplinary exchange and dialogue between researchers, physicians, and industry had been given a particularly high priority. "We want to encourage collaborations, to accelerate the translation of research results into new medicines", explains Horst Domdey, Managing Director of BioM and spokesman of the Bavarian Biotechnology Cluster.



The Biomedical Centre goes ONLINE

The Biomedical Centre of the LMU (Biomedizinische Centrum) has gone online. On their new homepage, you can find information on all research groups and areas which are located within the building. Just follow this link

Careers in Chemie, Pharma, Biotech und Medizin

9th of November 2016 at the LMU Munich

On 9th of November 2016 BioSysNet once again presented itself at the "Careers in Chemie, Pharma, Biotech und Medizin" in Munich. The event was directed towards students and applicants for career opportunities within the areas chemistry, pharma, biotechnology and medicine. In addition to BioSysNet, other companies such as Bristol-Myers Squibb, Covance, jobvector, VBio, BioM were present. 


Read more... 

Network meeting of BioSysNet

23rd of June 2016 in Würzburg

This year's network meeting of BioSysNet took place in Würzburg. Our thanks go to Dr. Ana Eulalio, Prof. Cynthia Sharma, Prof. Jörg Vogel and their teams for the excellent on-site support. The network meeting not only opened up room for discussion of current research results with colleagues, it was also a great networking event and enabled project leaders to discuss potential new projects and cooperations.


15th to 16th of June 2016 in Nürnberg

From 15th to 16th of June, BioSysNet was among the exhibitors at the joint booth of Bayern Innovativ at the MedTech Summit 2016 in Nürnberg. At this years summit, a large focus was placed on digitalization in medicine - this perfectly synergizes with BioSysNet's new and upcoming projects. 

BioSysNet at Analytica 2016

10th to 13th of May 2016, Messe Munich

At this year's Analytica, which took place from 10th to 13th of May at the Messe Munich, BioSysNet was sharing a booth with co-exhibitor Bio-M. The research network was represented by its main office staff who readily answered questions from the general public as well as from expert audience. More information on the Analytica 2016 can be found here

Inauguration of BioSys-M

19th of April 2016 at Campus Großhadern / Martinsried

On 19th of April 2016, the newly constructed BioSys-M building was finally inaugurated with an official opening ceremony. Guests included the Bavarian State Minister for Education, Science and the Arts, Dr. Ludwig Spaenle, Parliamentary State Secretary at the Federal Ministry of Education and Research, Stefan Müller, as well as the President of LMU, Prof. Dr. rer. pol. Bernd Huber. 


Prof. Ulrike Gaul of the LMU coordinated the construction project. The main office of BioSysNet, BayGene, FORPLANTA and Science meets School, headed by Dr. Ulrike Kaltenhauser, is excited to move into their new office space on the ground floor. Prof. Veit Hornung and part of the chair of Prof. Dirk Trauner for Chemical Biology and Chemical Genetics have already relocated to the new building. A fourth chair will include a unit for Computational Biology. Furthermore, Prof. Don Lamb, a specialist in the field of Biophysical Chemistry who is working with super resolution fluorescence microscopy, will move into the research complex. 


The newly constructed building on the hightech campus Großhadern / Martinsried offers space for about 200 employees. Within BioSys-M, the LMU accommodates its research on systems biology. Being a part of the gene center, it is located only 50 meters away from the gene center main building. A main focus of BioSys-M will be on cooperation and interdisciplinary collaboration. This is encouraged among other things through many seating areas on every floor as well as an inviting cafeteria on the ground floor. More information can be found in a detailed article (in German), see Download section. 

6th Conference on Systems Biology of Mammalian Cells - BioSysNet participating as main sponsor

6th-8th of April 2016 at Klinikum rechts der Isar

BioSysNet is very proud to have supported the 6th Conference on Systems Biology of Mammalian Cells (SBMC) 2016 as one of the main sponsors. Once again, the event has proven to be a huge success with as many as 270 participants, 140 poster presentations and 40 speakers, who turned the SMBC 2016 into one of the most interesting and interdisciplinary events of systems biology in Germany. 


Prof. Dr. Dr. Fabian Theis of the Mathematics Center of the Technical University of Munich, who is also an associate junior researcher within the BioSysNet network at the Helmholtz Center of Computational Biology, as well as Prof. Dr. Ursula Klingmüller of the German Cancer Research Center (DKFZ) successfully planned and implemented the conference. The BioSysNet research network was also supported on site by our members Dr. Fabiana Perocchi and PD Dr. Olaf Groß. More information can be found here.

New publication in the Slany research group

The research group of Professor Slany has achieved two new publications, including a research paper as well as a review article: 


Garcia-Cuellar MP, Büttner C, Bartenhagen C, Dugas C, Slany R.K. (2016) Leukemogenic MLL-ENL fusions induce alternative chromatin states to drive a functionally dichotomous group of target genes. CellReports,


Slany R.K. (2016) The molecular mechanics of mixed lineage leukemia, Oncogene, Review, Feb 29. doi: 10.1038/onc.2016.30


Congratulations on this success!

Interview with Dr. Ulrike Kaltenhauser -           Managing Director of BioSysNet, BayGene, FORPLANTA

In the new issue of "IZB im Dialog", the managing director of the research networks BioSysNet, BayGene and FORPLANTA talks about her job, her passion and the compatibility of family and career. Following a promising start in academic research, Ulrike Kaltenhauser later moved on to science management. Today, she looks back on many successful years in the management of several research networks. Download the whole article (in German) below. 

IZB im Dialog_2016_Dr. Kaltenhauser.pdf
Adobe Acrobat Dokument 297.8 KB

Prof. Dr. Eckhard Wolf -                                           one of Germany's most frequently cited scientists

The veterinarian and BioSysNet scientist Prof. Dr. Eckhard Wolf, head of the reproduction research at the LMU and professor of molecular animal breeding and biotechnology at the gene center, was recently acknowledged as the most frequently cited reproduction biologist (from 2009 to 2013) in the German-speaking world. 

This is a significant improvement to the last ranking, when Prof. Wolf "only" occupied position two. His colleague Dr. Valeri Zakhartchenko working at the same institution is now on rank two. 

New publication in the Vogel research group

The research group of Professor Jörg Vogel at the Institute for Molecular Infection Biology in Würzburg has recently published their excellent research work in Nature. Under the title "Dual RNA-seq unveils noncoding RNA functions in host-pathogen interactions", research results originating from a BioSysNet funded research project were published. We would like to congratulate the whole research group on this achievement!