2 Postdoctoral Positions
in the area of Neutrophil Biology / Mouse Immunology
The research group of Prof. Dr. Christoph Klein, Dr. von Hauner Children’s Hospital, Ludwig-Maximilians-University and Gene Center, Munich, Germany, offers
Two Postdoc Positions in Neutrophil Biology/Mouse Immunology
Our interdisciplinary and international research group studies basic mechanisms of the development and function of the blood and the immune system using infantile monogenetic disorders as paradigms. One main focus lies on the identification of novel genetic defects based on next generation sequencing (NGS). We are also interested in stem cell gene therapy. You will find more information at http://www.klein.genzentrum.lmu.de.
Currently, we are offering two Postdoc positions funded by the European Research Council (ERC Advanced Grant) with a focus on the biology of neutrophil granulocytes and mouse immunology. The successful candidates will analyze the genetic basis of myeloid cell defects and perform functional studies in mouse models.
• Highly motivated scientist (PhD or MD) who shares our enthusiasm for science and research
• Expertise in immunological, cell biological and genetic experimental techniques
• Willingness to perform animal research and experience with mouse models
• Very good English language skills
• Flexibility, proactive attitude and interpersonal skills
We offer to participate in an ambitious research project at the interface between basic research and clinic in a stimulating interdisciplinary environment and an excellently equipped laboratory. The position is initially limited to 2 years. The salary is according to TV-L. The Munich University Hospital is an equal opportunity employer. Handicapped candidates with equal qualifications will be given preference. We regret that we are unable to cover travel expenses for interviews. For further information please contact Dr. Regina Steck (089/4400-57977).
The Munich University Hospital is one of the largest and most efficient university medical centers in Germany and Europe. The Gene Center is an interdisciplinary institute of the LMU providing a dynamic, interactive and internationally diverse scientific environment, located within the biomedical research campus in Munich-Großhadern.
To apply, please send a PDF-file with the subject „Name.First name:Postdoc“ to Regina.Steck@med.uni-muenchen.de or send your written application to Prof. Dr. Dr. Christoph Klein, Ärztlicher Direktor, Kinderklinik und Kinderpoliklinik im Dr. von Haunerschen Kinderspital, LMU München, Lindwurmstr. 4, 80337 München, Germany.
Postdoctoral Position and PhD Position
in a drug development project at the Department of Molecular Pediactrics, Dr. von Hauner Children's Hospital
The Department of Molecular Pediatrics, Dr. von Hauner Children’s Hospital, Ludwig-Maximilians-University, Munich, Germany offers the positions of
1 Postdoc (E13)
1 PhD (E13/2)
for a 3 years collaborative research project. The project is entitled "Identification of pharmacological chaperones for the treatment of the protein misfolding disorders phenylketonuria and medium-chain acyl-CoA dehydrogenase deficiency”.
Orphan genetic diseases are frequently associated with the phenotype of protein misfolding. Missense mutations lead to conformational destabilization and degradation of the affected protein eventually leading to a loss-of-function phenotype. For a number of diseases small molecule compounds (pharmacological chaperones) have been identified that bear the potential of conformational stabilization of the misfolded proteins. Our research of the past years focused on the molecular mechanisms behind protein misfolding disorders with loss-of-function phenotype, such as phenylketonuria (PKU) and medium-chain acyl-CoA dehydrogenase deficiency (MCADD). Moreover, our work contributed to the development of an approved pharmacological chaperone drug for the treatment of phenylketonuria. The current project aims to identify novel small molecule compounds with pharmacological chaperone efficacy for PKU and MCADD. In collaboration with biotech companies (Crelux, Martinsried; Nanotemper, Munich), the full sequence of high-throughput hit identification, functional validation, characterization of binding modes, and co-crystallization will be covered.
Applicants should have a background in biochemistry, chemistry, pharmacy or biology as well as good knowledge on methods of protein purification and protein biochemistry. Experience in structural biology is welcome but not mandatory.
We offer an academic working environment in a multidisciplinary team of physicians, chemists, and biologists. The project will cover aspects of both basic as well as translational research. The work in the laboratories of the children’s hospital in strong collaboration with biotech companies will provide in-depth insight into the process of drug development.
Soeren W. Gersting, MD
in bio-molecular medicine and scientific management of a large EU funded project
The Pediatric Pneumology research group of Prof. Dr. Matthias Griese in the Research Center of Dr. von Hauner Children’s Hospital, Ludwig-Maximilians University Munich, Germany is offering a
Postdoctoral Position in bio-molecular medicine and scientific management of a large EU funded project.
The position will be open starting from 01.02.2014 (TV-L 13). As the coordinators of the Project "Orphans Unite: chILD better together – European Management Platform for Childhood Interstitial Lung Diseases" (chILD-EU) we are directing the development of this international consortium. Here, the leading European clinical scientists and paediatric pulmonologists collaborate to assemble and follow children with well defined rare pulmonary disease entities in a pan-European database and biobank. The project will lead to a better care of patients afflicted by rare chILD and lead to improved quality of life for children with these incurable diseases.
The position encompasses on the one hand the management coordination of the register and biobank, participation in the structural implementation of studies, the cooperation with the programming group, the chILD Advisory Groups and the chILD-EU Trial Panels to guarantee adequate implementation of the electronic data capture system. On the other hand, molecular and cellular mechanisms of some very specific genetic interstitial lung diseases will be investigated in great detail in cell culture and patient samples.
We are looking for a highly motivated, team-orientated individual who finds joy in coordination and scientific work and is able to manage scientific projects. Practical and theoretical expertise in molecular biology and genetics with the necessary informatics are indispensible. Also English language proficiency (both spoken and written) and skills in communication to a wide range of scientists and lay people as well as writing of scientific publications are required.
We are offering a scientifically motivating, international environment with an excellence in management and research with links to academics, industry and lay people, together with a superb opportunity for scientific development and a very friendly working atmosphere. Candidates should send their full application in German or English including CV, cover letter, copies of relevant documents and contact data of two references per E-mail to:
Prof. Dr. Matthias Griese
Dr. von Hauner Children’s Hospital
Tel. : +49-(0)89-5160-7870 or +49-(0)89-5160-7871
Position as an assistant scientist (wissenschaftliche Hilfskraft) available at Dr. Fabiana Perocchi's lab
A HiWi position is available at the Gene Center of the Ludwig-Maximillians University in Grosshadern/Munich starting from Nov 2013.
Our research group aims at reconstructing mitochondrial signaling networks that generate in response to physiological and pathophysiological stimuli. To this goal, we combine systems biology approaches with traditional genetic,biochemical, and physiological studies in yeast, mouse, and human cells.
In collaboration with the research teams composed of biologists and mathematicians, the successful candidate will work on the following potential projects: the development of algorithms dedicated to the discovery of new protein functions involved in mitochondria biology, the setup of mathematical models to understand mitochondrial calcium signaling pathways, large-scale data analysis, and development of in-house databases.
A bachelor degree in any of the following subjects is preferred: Mathematics, computer science, statistics, bioinformatics and computational biology, together with a high interest in large-scale biological data analysis and modeling.
-Advanced knowledge in unix environment
-Advanced knowledge in programming in PERL. Knowledge of Matlab would be preferred.
-Basic knowledge of rational database
-Basic knowledge of biology and bioinformatics.
-Basic knowledge of differential equations and statistics.
-Basic knowledge of parallel programming.
Applications including CV and a short summary of past experiences (if any) should be sent to Dr. Fabiana Perocchi and Dr. Yiming Cheng at: